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Description
CD55/DAF His Tag Protein, MouseProduct Specification Species Mouse Synonyms CD55,DAF,CR,CROM,TC Accession Q61475 Amino Acid Sequence Asp35 T361, with C 10*His Expression System HEK293 Molecular Weight 45 72kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation.
Product Specification
| Species | Mouse |
| Synonyms | CD55,DAF,CR,CROM,TC |
| Accession | Q61475 |
| Amino Acid Sequence | Asp35-T361, with C-10*His |
| Expression System | HEK293 |
| Molecular Weight | 45-72kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Journal List Immunology v.100(4); 2000 Aug PMC2327033. |
Background
CD55, also known as DAF or decay acceleration factor, is a 70-75 kDa member of the RCA protein family that is characterized by four to 30 SCRS (short consistent repeats) in its plasma exposure area. It prevents the assembly of the C3bBb complex (the C3-convertase of the alternative pathway) or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex. DAF seems to exert different functions beyond its immunological role such as promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility.
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