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Description
Biotinylated TROP2/TACSTD2 His&Avi Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms TACSTD2,GA733 1,M1S1,TROP2 Accession XP_001114599. 1 Amino Acid Sequence Gln31 Thr274, with C terminal His and Avitag Expression System HEK293 Molecular Weight 40 50kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <1EU g Tag Avi Tag, His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid
Product Specification
| Species | Cynomolgus |
| Synonyms | TACSTD2,GA733-1,M1S1,TROP2 |
| Accession | XP_001114599.1 |
| Amino Acid Sequence | Gln31-Thr274, with C-terminal His and Avitag |
| Expression System | HEK293 |
| Molecular Weight | 40-50kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Tag | Avi Tag, His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Takamichi Ito, Keiko Tanegashima, Yuka Tanaka, Hiroki Hashimoto, Maho Murata, Yoshinao Oda, Yumiko Kaku-Ito. (2021). Int J Mol Sci. 22(14):7706 2. Yeonjin Jeon, Uiree Jo, Jongmoo Hong, Gyungyub Gong & Hee Jin Lee. (2022). Trophoblast cell-surface antigen 2 (TROP2) expression in triple-negative breast cancer. Research article. 1014 (2022) |
Background
Trophoblast cell-surface antigen 2 (TROP2), also known as tumor-associated calcium signal transducer 2 (TACSTD2), is a transmembrane glycoprotein with high homology to the epithelial cell. TROP2 was discovered first in trophoblast cells as a surface marker. Gene TACSTD2 located on chromosome 1p32 encodes TROP2. TROP2 consists of extracellular and transmembrane domains and a cytoplasmic tail. TROP2 undergoes intramembrane proteolysis and is cleaved into a large extracellular fragment and a short intracellular fragment. TROP2 increases intracellular calcium concentration, decreases fibronectin binding and cell adhesion, and increases cell motility. TROP2 is overexpressed in several carcinomas, such as colorectal, pancreatic, gastric, oral squamous cell carcinoma, ovarian, and breast cancers, compared with the corresponding normal tissue. Because TROP2 overexpression is associated with poor survival in patients with solid tumors, TROP2 has been considered a potential target for anticancer therapy. In studies of breast and lung cancers, TROP2 inhibition exerted anticancer effects.
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