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Description
TGF-β1 Protein, Mouse/RatProduct Specification Species Mouse, Rat Synonyms Transforming growth factor beta 1,TGF 1 Accession P04202 Amino Acid Sequence Ala279 Ser390 Expression System HEK293 Molecular Weight 12 13 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer 4mM HCl Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in 4mM HCl after rapid
Product Specification
| Species | Mouse, Rat |
| Synonyms | Transforming growth factor beta-1,TGF-β1 |
| Accession | P04202 |
| Amino Acid Sequence | Ala279-Ser390 |
| Expression System | HEK293 |
| Molecular Weight | 12-13 kDa (Reducing) |
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 4mM HCl |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in 4mM HCl after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Annu Rev Immunol. 2006:24:99-146. |
Background
Transforming growth factor beta 1 (TGFβ1) is the prototype of a growing superfamily of peptide growth factors and plays a prominent role in a variety of cellular processes, including cell-cycle progression, cell differentiation, reproductive function, development, motility, adhesion, neuronal growth, bone morphogenesis, wound healing, and immune surveillance. TGF-β1, TGF-β2 and TGF-β3 signal via the same heteromeric receptor complex, consisting of a ligand binding TGF-β receptor type II (TβR-II), and a TGF-β receptor type I (TβR-I). Signal transduction from the receptor to the nucleus is mediated via SMADs. TGF-β expression is found in cartilage, bone, teeth, muscle, heart, blood vessels, haematopoitic cells, lung, kidney, gut, liver, eye, ear, skin, and the nervous system.
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