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Description
B7-H4 Recombinant Rabbit mAb,PBS Only (SDT-314-447)Product Specification Host Rabbit Antigen B7 H4 Synonyms V set domain containing T cell activation inhibitor 1, B7 homolog 4, B7h. 5, Protein B7S1, T cell costimulatory molecule B7x, VTCN1 Immunogen Recombinant Protein Location Cell membrane Accession Q7Z7D3 Clone Number SDT 314 447 Antibody Type Recombinant mAb Application WB, IHC P, ICC, IP, IF Reactivity Hu Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | B7-H4 |
| Synonyms | V-set domain-containing T-cell activation inhibitor 1, B7 homolog 4, B7h.5, Protein B7S1, T-cell costimulatory molecule B7x, VTCN1 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q7Z7D3 |
| Clone Number | SDT-314-447 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, IP, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:200 | |
| IP | 1:50 | |
| IHC | 1:400 | |
| ICC | 1:50 | |
| IF | 1:500 |
Background
B7-H4 is a transmembrane protein that binds an unknown receptor on activated T cells resulting in inhibition of T-cell effector function via cell cycle arrest, decreased proliferation, and reduced IL-2 production. B7-H4 is up-regulated on the surface of cancer cells and immunosuppressive tumor-associated macrophages (TAMs) in a variety of human cancers. Notably, B7-H4 expression levels inversely correlate with patient survival in ovarian cancer, cholangiocarcinoma, breast cancer and endometrial cancer, making B7-H4 an attractive candidate for therapeutic intervention.
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