SKU: 20992811865

Optineurin Recombinant Rabbit mAb (S-2030-40)

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Description

Optineurin Recombinant Rabbit mAb (S-2030-40)Product Specification Host Rabbit Antigen Optineurin Synonyms E3 14. 7K interacting protein (FIP 2); Huntingtin yeast partner L; Huntingtin interacting protein 7 (HIP 7); Huntingtin interacting protein L; NEMO related protein; FIP2; GLC1E; HIP7; HYPL; NRP; OPTN Immunogen Synthetic Peptide Accession Q96CV9 Clone Number S 2030 40 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample HeLa, A172, HDLM 2 Purification

Product Specification


Host Rabbit
Antigen Optineurin
Synonyms E3-14.7K-interacting protein (FIP-2); Huntingtin yeast partner L; Huntingtin-interacting protein 7 (HIP-7); Huntingtin-interacting protein L; NEMO-related protein; FIP2; GLC1E; HIP7; HYPL; NRP; OPTN
Immunogen Synthetic Peptide
Accession Q96CV9
Clone Number S-2030-40
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Positive Sample HeLa, A172, HDLM-2
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:200 Hu

Background

Optineurin (OPTN) is a 67 kDa multifunctional cytosolic adaptor protein, originally identified as FIP-2 (E3-14.7K-interacting protein) and later implicated in normal-tension glaucoma, amyotrophic lateral sclerosis, Paget’s disease of bone, and Crohn’s disease. It contains several domains (e.g., leucine zipper, zinc finger, ubiquitin-binding domain, LC3-interacting region) enabling interaction with proteins such as Rab8, myosin VI, and TBK1, thus participating in vesicular trafficking, Golgi maintenance, NF-κB-mediated antiviral signaling, and autophagy (including aggrephagy, mitophagy, and xenophagy). Notably, OPTN acts as an autophagy receptor, recruiting ubiquitinated mitochondria to autophagosomes during mitophagy via its ubiquitin-binding activity, and its mutations (e.g., E50K, M98K) disrupt autophagy and lead to neurodegeneration and retinal ganglion cell death.

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SKU: 20992811865

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4.3 ★★★★★
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Sviatlana Hrachova
Charlottesville, US
★★★★★ 5
Biodance Collagen Gel Toner Pads, Pore Minimizer for...
Scent: Collagen
Very good sponges! They gently cleanse the skin, remove impurities well, and leave my face feeling fresh and hydrated. I use them every morning and evening, and my skin feels softer and smoother after each use. Great quality and very pleasant to use. Highly recommend!
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Reviewed in the United States on March 15, 2026
B
Verified Purchase
bobbid15
Pawtucket, US
★★★★★ 5
Immediate Results After only Three Days of Use
Scent: Collagen, Scent: Collagen
I’ve only been using this product for about a week now, but the results have been almost immediate when paired with the Pore Perfecting Collagen Peptide Serum . Within just three days of using these products every morning and evening, I noticed a marked improvement in tone and texture. The lines on my face appeared to soften and my large pores were less obvious. I also used these products with a pore reducing cleanser, but I was absolutely amazed by the immediate and dramatic difference using these products. I’ve used numerous different products in the past, some which came with a hefty price tag, and have never been so surprised or impressed with the quick and obvious results as I have using these products. I was so impressed, I immediately purchased more to make sure I wouldn’t run out. Not only is the cost of these products very reasonable, these are products that actually produce immediate and very noticeable results. I’m so very happy I came across these and chose to try them! I’m attaching be for and after pictures to show just how much difference these Bodance products have made. These are terrible pictures of me, but it DOES show the results of using these products for just a few days.
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Reviewed in the United States on February 8, 2026
N
Verified Purchase
Natasha Izquierdo
Whiting, US
★★★★★ 5
Super soft, cozy, and great quality Dog Bed
Size: Small 24"x18", Color: White, Size: Small 24"x18", Color: White
This pet mat exceeded my expectations. The material is incredibly soft and plush, and you can tell right away that it’s made with comfort in mind. My pet laid on it immediately, which is always the best sign. It provides just the right amount of cushioning without being too thick or heavy. The quality is excellent — the stitching feels sturdy, the fabric doesn’t shed, and it holds its shape well with regular use. It’s lightweight and easy to move around, making it perfect for use in crates, on the floor, or even on furniture for extra protection. Cleaning is simple, and it still looks great after use. Overall, this mat offers great durability, ease of use, and excellent value for money. It’s stylish, practical, and extremely comfortable for pets. I would absolutely recommend this to anyone looking for a cozy, high-quality mat for their dog or cat 🐾
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Reviewed in the United States on December 24, 2025
R
Verified Purchase
Ryan
Houston, US
★★★★★ 5
Cushion for the pooch’n
Size: Small 24"x18", Color: Brown
I’ve been using the ULIGOTA Dog Bed Crate Pad Plush Soft Crate Bed in my dog’s crate for daily resting and overnight sleep. Right out of the package, it’s clearly designed for comfort first. The plush top feels soft and inviting, and it immediately makes the crate look more like a cozy sleeping space rather than a hard plastic tray. Once fluffed up, it provides a decent layer of cushioning that’s noticeably more comfortable than a bare crate floor or thin mat. In terms of fit, it sits well inside standard crate sizes and doesn’t bunch up too badly once settled. The anti-slip bottom helps keep it in place during normal movement, which is especially helpful for dogs that reposition a lot while sleeping. Comfort-wise, it works well for small to medium dogs that just need light padding. It’s warm and soft enough for everyday use, and most dogs seem to settle into it quickly. However, it’s not a high-density or orthopedic-style bed, so it doesn’t offer much support for dogs that need joint relief or extra structure. Durability is average. It holds up fine under normal sleeping use, but it’s not ideal for heavy chewers or dogs that dig aggressively. Like most plush crate pads, it’s more of a comfort layer than a rugged long-term solution. Pros: very soft plush surface, comfortable for everyday crate use, easy fit in standard crates, non-slip backing helps stability Cons: not chew-resistant, limited support for heavier or senior dogs, cushioning is on the thinner side Overall: a solid, budget-friendly crate pad that improves comfort and warmth significantly over a bare crate, but best suited for calm sleepers rather than heavy chewers or dogs needing orthopedic support.
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Reviewed in the United States on April 19, 2026
C
Verified Purchase
Courtney D
Dallas, US
★★★★★ 5
Soft dog bed perfect for small breeds
Size: Medium 30"x20", Color: White
This dog bed is very soft and fit perfectly in my dogs crate. I like that it came vacuum sealed and was really easy to open and leave out to expand. The material is durable and it is perfect thickness for a small breed dog. My Maltese puppy loves it and has been sleeping so well on it, she is very comfortable. The material is durable and easily washable, I already had to run it through the washing machine. Well worth the price and easy to fit in a crate or small space.
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Reviewed in the United States on April 23, 2026

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