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Description
TIA1 Recombinant Rabbit mAb (S-R026)Product Specification Host Rabbit Antigen TIA1 Synonyms p40 TIA 1 Immunogen N A Location Cytoplasm, Nucleus Accession P31483 Clone Number SDT R026 Antibody Type Rabbit mAb Application WB, ICC, FC, IP Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as supplied Dilution
Product Specification
| Host | Rabbit |
| Antigen | TIA1 |
| Synonyms | p40-TIA-1 |
| Immunogen | N/A |
| Location | Cytoplasm, Nucleus |
| Accession | P31483 |
| Clone Number | SDT-R026 |
| Antibody Type | Rabbit mAb |
| Application | WB, ICC, FC, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| ICC | 1:500 | null |
| WB | 1:1000 | null |
| IP | 1:25 | null |
| FC | 1:500 | null |
Background
TIA1 or Tia1 cytotoxic granule-associated RNA binding protein is a 3'UTR mRNA binding protein that can bind the 5'TOP sequence of 5'TOP mRNAs. It is associated with programmed cell death (apoptosis) and regulates alternative splicing of the gene encoding the Fas receptor, an apoptosis-promoting protein. Under stress conditions, TIA1 localizes to cellular RNA-protein conglomerations called stress granules. It is encoded by the TIA1 gene.Mutations in the TIA1 gene have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, and Welander distal myopathy. It also plays a crucial role in the development of toxic oligomeric tau in Alzheimer's disease.
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