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Description
JunB Recombinant Rabbit mAb (S-R294)Product Specification Host Rabbit Antigen JunB Synonyms Transcription factor JunB; Transcription factor AP 1 subunit JunB Location Nucleus Accession 017275 Clone Number S R294 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM, ChIP Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability &
Product Specification
| Host | Rabbit |
| Antigen | JunB |
| Synonyms | Transcription factor JunB; Transcription factor AP-1 subunit JunB |
| Location | Nucleus |
| Accession | 017275 |
| Clone Number | S-R294 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM, ChIP |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC | 1:500 | |
| ICC | 1:500 | |
| ICFCM | 1:500 | |
| ChIP | 1:20-1:50 |
Background
Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene. Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'. In addition, JunB proteins are important regulators of cytokine expression and the immune response in skin. Skin specific JunB deficiency in mice has been associated with numerous skin pathologies including psoriasis-like disease, systemic lupus erythematosus, ulcerative skin lesions, prolonged inflammation with delayed tissue remodeling19 and myeloproliferative disease.
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