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Description
SREBP2 Recombinant Rabbit mAb (S-2701-1)Product Specification Host Rabbit Antigen SREBP2 Synonyms Sterol regulatory element binding protein 2; SREBP 2; Class D basic helix loop helix protein 2 (bHLHd2); Sterol regulatory element binding transcription factor 2; BHLHD2; SREBF2 Immunogen Synthetic Peptide Location Nucleus, Endoplasmic reticulum membrane, Golgi apparatus membrane Accession Q12772 Clone Number S 2701 1 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IF
Product Specification
| Host | Rabbit |
| Antigen | SREBP2 |
| Synonyms | Sterol regulatory element-binding protein 2; SREBP-2; Class D basic helix-loop-helix protein 2 (bHLHd2); Sterol regulatory element-binding transcription factor 2; BHLHD2; SREBF2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus, Endoplasmic reticulum membrane, Golgi apparatus membrane |
| Accession | Q12772 |
| Clone Number | S-2701-1 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Hu, Mk |
| Positive Sample | HeLa, HepG2, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Mk |
| IHC-P | 1:250 | Hu |
| ICC | 1:500 | Hu |
| IF | 1:500 | Hu |
Background
Sterol regulatory element-binding protein 2 (SREBP2) is a membrane-bound transcription factor that acts as the master sensor and amplifier of cellular cholesterol demand: in cholesterol-replete ER membranes it is held inactive through association with SCAP and Insig, but when cholesterol falls SCAP escorts SREBP2 to the Golgi where site-1 and site-2 proteases release its ~480-amino-acid N-terminal fragment; this mature form enters the nucleus, binds sterol response elements, and drives expression of nearly every gene required for cholesterol acquisition (HMGCR, HMGCS, LDLR) and efflux control (ABCA1, ABCG5/8), while also cross-talking with SREBP1c to coordinate overall lipid homeostasis, making SREBP2 the central switch that keeps mammalian cell membranes optimally functional.
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