SKU: 14866102891

HVEM/TNFRSF14 His Tag Protein, Human

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Description

HVEM/TNFRSF14 His Tag Protein, HumanProduct Specification Species Human Synonyms TNFRSF14,ATAR, HVEA, LIGHTR, TR2, CD270 Accession Q92956 1 Amino Acid Sequence Leu39 Val202, with C terminal His Expression System HEK293 Molecular Weight 30 43kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water

Product Specification


Species Human
Synonyms TNFRSF14,ATAR, HVEA, LIGHTR, TR2, CD270
Accession Q92956-1
Amino Acid Sequence Leu39-Val202, with C-terminal His
Expression System HEK293
Molecular Weight

30-43kDa (Reducing)

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4.
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Steinberg MW, et al. (2008) A crucial role for HVEM and BTLA in preventing intestinal inflammation. J Exp Med. 205(6): 1463-76. 

2.Pasero C, et al. (2009) A role for HVEM, but not lymphotoxin-beta receptor, in LIGHT-induced tumor cell death and chemokine production. Eur J Immunol. 39(9): 2502-14.

Background

Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily.It is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling. However, recent studies have revealed that HVEM may be viewed as a molecular switch, capable of facilitating both stimulatory and inhibitory cosignaling in T cells. Substantial evidence from both human disease and from experimental mouse models has indicated that dysregulation of the LIGHT-HVEM-BTLA cosignaling pathway can cause inflammation in the lung and in mucosal tissues.

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SKU: 14866102891

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4.2 ★★★★★
Based on 19 reviews
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Verified Purchase
Brigette Ritchie
Louisville, US
★★★★★ 5
Great toy
Size: Small (9 in), Style: 2 Knot Rope Bone
I got this because my puppy chews through the other kinds of rope toys. This one is laying though. Only thing is, she's eating off the loose strings. Lol So she's pooping strings all the time
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 14, 2026
J
Verified Purchase
Jeffrey T DeLapp
Dallas, US
★★★★★ 5
The strings on the end are super engaging and the rope itself holds up really well
Size: Small (9 in), Style: 2 Knot Rope Bone
Super cost effective way to redirect chewing!! Our 4 month old corgi quickly made this is favorite toy. He loves the strings on the side and tugs on it endlessly, and the main rope was pretty firm at first but has softened up while maintaining its strength. Highly recommend as an interactive toy or just something for your dog to chew on their own so you can take some time to chill on your own!
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Reviewed in the United States on July 25, 2024
J
Verified Purchase
Julie
Draper, US
★★★★★ 3
Not for aggressive chewers!
Size: Large (14 in), Style: 2 Knot Rope Bone
At first glance, this rope toy seemed sturdy and well made. However, within an hour of my Vizsla chewing on it, she had already bitten off and unfortunately swallowed several of the fringes. The center of the rope also began to unravel. This toy may be suitable for smaller dogs or those that aren’t aggressive chewers, but I wouldn’t recommend it for large dogs or heavy chewers. Additionally, while it may measure 14 inches before being knotted at the ends, the total length is shorter than advertised.
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Reviewed in the United States on April 5, 2026
B
Verified Purchase
BErickson
Waukegan, US
★★★★★ 5
Two knots, Not 3…
Size: Large (14 in), Style: 2 Knot Rope Bone
Been subscribed & saving on 3 knot version for years. My dogs gnaw through the center knot and they quickly unravel. This 2 knot version seems to last much longer.
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Reviewed in the United States on October 19, 2025
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Verified Purchase
Craig Curran
Boise, US
★★★★★ 5
Longest living toy ever!
Style: Variety Pack - Large (3-pack), Style: Variety Pack - Large (3-pack)
This review is 2 years in the making! Purchased over 2 years ago, all three are still in active play, still squeek, with no holes.
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Reviewed in the United States on May 18, 2026

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