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Description
FGF-21 Protein, HumanProduct Specification Species Human Synonyms FGF 21; Fibroblast Growth Factor 21, FGF 21, FGF21 Accession Q9NSA1 1 Amino Acid Sequence His29 Ser209, with N terminal His Tag Expression System HEK293 Molecular Weight 25 28 KDa(Reducing) Purity 95%, by SDS PAGE under reducing conditions Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 2, 5% trehalose Reconstitution Reconstitute at
Product Specification
| Species | Human |
| Synonyms | FGF-21;Fibroblast Growth Factor 21, FGF-21, FGF21 |
| Accession | Q9NSA1-1 |
| Amino Acid Sequence | His29-Ser209, with N-terminal His Tag |
| Expression System | HEK293 |
| Molecular Weight | 25-28 KDa(Reducing) |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.2, 5% trehalose |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
Fibroblast growth factor 21 (FGF-21) is a member of the FGF gene family. According to its structure, it is further classified as a member of the FGF19 subfamily. The subfamily includes FGF-19,-21 and-23. FGF-21 is an effective adipocyte glucose uptake activator that protects animals from diet-induced obesity when overexpressed in transgenic mice and reduces blood glucose and triglyceride levels during treatment in diabetic rodents. Some studies have shown that FGF-21 is a biomarker for the diagnosis of mitochondrial diseases. FGF-21 can cross the blood-brain barrier and regulate the phosphorylation cascade and gene expression in the whole hypothalamus. Intracerebroventricular injection of FGF21 can increase metabolic rate and insulin sensitivity in rats, but the site of action is not clear.
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