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Description
IL-31 Protein, CanineProduct Specification Species Canine Synonyms IL 31,IL31,Interleukin 31 Accession C7G0W1 Amino Acid Sequence Ser24 Gln159 with C terminal 8*His MSHMAPTHQLPPSDVRKIILELQPLSRGLLEDYQKKETGVPESNRTLLLCLTSDSQPPRLNSSAILPYFRAIRPLSDKNIIDKIIEQLDKLKFQHEPETEISVPADTFECKSFILTILQQFSACLESVFKSLNSGPQHHHHHHHH Expression System E. coli Molecular Weight 17kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance
Product Specification
| Species | Canine |
| Synonyms | IL-31,IL31,Interleukin-31 |
| Accession | C7G0W1 |
| Amino Acid Sequence |
Ser24-Gln159 with C terminal 8*His MSHMAPTHQLPPSDVRKIILELQPLSRGLLEDYQKKETGVPESNRTLLLCLTSDSQPPRLNSSAILPYFRAIRPLSDKNIIDKIIEQLDKLKFQHEPETEISVPADTFECKSFILTILQQFSACLESVFKSLNSGPQHHHHHHHH |
| Expression System | E.coli |
| Molecular Weight | 17kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 5% Trehalose. |
| Reconstitution | econstitute at 0.1-0.5mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. J Allergy Clin Immunol. 2023 Jul 13;S0091-6749(23)00888-6. Online ahead of print. |
Background
IL-31 which produced by activated Th2-type T cells. IL-31 signals through a receptor composed of IL-31 receptor A and oncostatin M receptor. IL-31 activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR. IL-31 has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis. Patients with atopic dermatitis, chronic spontaneous urticaria, allergic contact dermatitis, prurigo nodularis, primary cutaneous lymphoma and mastocytosis exhibit increased serum levels of IL-31 protein and elevated IL-31 mRNA in the skin.
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4.5 ★★★★★
Based on 21 reviews
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Product Reviews
★★★★★ 4
A bit wider than I expected
Style: Coyote
I thought this was going to be a "flat" toy but was a bit surprised to see that it was more of a 3D shape than flat. It's unfortunately a bit too wide for my small/medium sized terrier so he really only grabs and chews on the tail and ears. It is pretty durable though and has held up well.
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Reviewed in the United States on April 20, 2026
★★★★★ 5
Toughest dog toy we've ever owned! Jasper approved!
Style: Elk, Style: Elk
If you are the owner of a "power chewer" who usually turns standard plushies into a snowstorm of stuffing in under five minutes, the HOUND2O Elk Stuffed Animal is the heavy-duty solution you’ve been looking for. This isn't just a toy; it’s a rugged piece of outdoor-grade gear that manages to stay "plush" while being nearly indestructible.
Here is why this elk is the gold standard for aggressive chewers.
The "Ballistic" Build
The secret to its toughness lies in the materials. Unlike cheap fleece or thin polyester, the HOUND2O Elk is engineered for extreme durability.
Ballistic Nylon Shell: The body is wrapped in high-denier ballistic nylon—the same type of material used in tactical gear. It’s incredibly resistant to punctures and tears from sharp canine teeth.
Reinforced TPR Accents: The "antlers" and specific high-wear points are reinforced with Thermoplastic Rubber (TPR). This gives your dog a satisfying, grippy texture to gnaw on without compromising the toy’s structural integrity.
Extreme Stitching: The seams are double-stitched and recessed, making it nearly impossible for a dog to find a "weak spot" to start a rip.
Built for Adventure: This toy is marketed for "outdoor adventures," and it truly lives up to that branding:
Water-Resistant & Buoyant: Unlike most stuffed animals that become soggy, heavy sponges, this elk is water-resistant and it floats. It’s the perfect companion for a trip to the lake or a game of fetch in the pool.
Easy to Clean: Because the material is so dense, mud and slobber don't soak in deeply. A quick rinse with a hose or a wipe-down with soap and water makes it look brand new after a day in the dirt.
High Visibility: The vibrant colors and distinct shape make it easy to spot in tall grass or murky water, so you won't lose it during a long-range game of fetch.
Engaging (But Tough) Squeaker
For many aggressive chewers, the goal is to "silence" the squeaker as fast as possible.
Protected Internal Squeaker: The squeaker is buried deep within the ballistic layers, making it much harder for a dog to pinpoint and puncture. It provides that high-value auditory feedback that keeps dogs engaged without being an easy "kill point" for the toy.
Performance at a Glance
Durability - Ballistic nylon and TPR are a "power chewer" dream.
Versatility - Floats, easy to clean, and works indoors/outdoors.
Engagement - Mixed textures (nylon + rubber) keep dogs interested.
Value - Outlasts 10 standard plush toys combined.
The HOUND2O Elk is a 10/10 for any pet parent tired of throwing away shredded toys. It is incredibly tough, intelligently designed, and built to withstand the "ruffest" play. While no toy is truly 100% indestructible for every single dog, this is as close as a plush-style toy can possibly get.
If your dog loves the "thrill of the hunt," try hiding this elk in some tall grass or bushes outside. Its tough shell can handle the brush, and it’s a great way to provide mental stimulation alongside a heavy chewing session!
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Reviewed in the United States on March 13, 2026
★★★★★ 2
Not as durable as it looks
Style: Snake
Our half pittbull and half american bulldog tore this apart in 5min.
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Reviewed in the United States on April 27, 2026
★★★★★ 5
Good looking toy that has held up well
Style: Coyote, Style: Coyote
Very durable toy that our little dog especially loves. It's the perfect size for a small dog and she doesn't destroy toys anyway so it's been great. It does feel very durable though and would take our chewer a little while to get to it as well.
I'm not sure it looks like a coyote but the dogs don't seem to mind. It's an attractive toy that looks great and is constructed well so it's not like a slobbery mess when left out.
Good value for the money and would make a great gift because it looks higher quality than most toys.
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Reviewed in the United States on April 14, 2026
★★★★★ 1
May be ballistic nylon, but the seams are flimsy.
Style: Gator, Style: Gator
I really wanted my pup to like this toy because it looks great and feels solid at first. The design is fun, the material seems tough, and it definitely gives the impression that it can handle some rough play. Unfortunately, that didn’t turn out to be the case at all.
After just about 5 minutes of play, the top seam split open and stuffing started coming out. This wasn’t even extreme chewing, just normal play, and it failed almost immediately. As you can see in the photos, the tear happened right along the top seam, which is exactly where you’d expect a toy to be reinforced. Once it opened up, the toy was essentially done.
For something marketed as ballistic nylon, this was really disappointing. It might be fine for very gentle dogs, but if your dog has even moderate chewing habits, this likely won’t last. Based on my experience, I wouldn’t recommend it. especially at 19.99 which is the price at time of my review, I feel it does not offer good value for money.
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Reviewed in the United States on April 9, 2026
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