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Description
PPIF/Cyclophilin F Recombinant Rabbit mAb (S-2043-61)Product Specification Host Rabbit Antigen PPIF Cyclophilin F Synonyms Peptidyl prolyl cis trans isomerase F, mitochondrial; PPIase F; Cyclophilin D (CyP D; CypD); Mitochondrial cyclophilin (CyP M); Rotamase F; CYP3 Immunogen Synthetic Peptide Location Mitochondrion Accession P30405 Clone Number S 2043 61 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HeLa, HEK 293, HepG2, MCF7, mouse heart,
Product Specification
| Host | Rabbit |
| Antigen | PPIF/Cyclophilin F |
| Synonyms | Peptidyl-prolyl cis-trans isomerase F, mitochondrial; PPIase F; Cyclophilin D (CyP-D; CypD); Mitochondrial cyclophilin (CyP-M); Rotamase F; CYP3 |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | P30405 |
| Clone Number | S-2043-61 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, HEK-293, HepG2, MCF7, mouse heart, rat heart |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:200 | Hu |
| ICC | 1:500 | Hu |
Background
PPIF/Cyclophilin F protein is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, which catalyzes the isomerization of proline imide peptide bonds in oligopeptides, thereby accelerating protein folding. It is a critical component of the mitochondrial permeability transition pore (mPTP) in the inner mitochondrial membrane, and its activation is associated with the induction of apoptotic and necrotic cell death. Cyclophilin F also interacts with mitochondrial p53/TP53 to activate necrosis induced by oxidative stress and regulates mitochondrial membrane F(1)F(0) ATP synthase activity. Additionally, it has anti-apoptotic activity independent of mPTP, cooperating with BCL2 to inhibit cytochrome c-dependent apoptosis.
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