SKU: 56693079521

Protein Folding Disorders of the Central Nervous System

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Protein Folding Disorders of the Central Nervous SystemThis exciting new book explores the dark side of the molecular protein assembly bringing an updated view of how failures in the homeostatic mechanisms that efficiently regulate protein folding leads to the accumulation of structurally abnormal pathogenic assemblies, encompassing an emerging group of diseases collectively known as "Protein Folding Disorders." This complex and diverse group of chronic and progressive entities are bridged together by

This exciting new book explores the dark side of the molecular protein assembly bringing an updated view of how failures in the homeostatic mechanisms that efficiently regulate protein folding leads to the accumulation of structurally abnormal pathogenic assemblies, encompassing an emerging group of diseases collectively known as "Protein Folding Disorders." This complex and diverse group of chronic and progressive entities are bridged together by their relationship to structural transitions in the native state of specific proteinaceous components, which for reasons poorly understood, convert into polymeric aggregates that generate poorly soluble tissue deposits and which are considered today the culprit of the disease pathogenesis in their respective diseases. Despite the diversity in the amino acid sequence of the different proteins involved in these heterogeneous disorders, all the pathologic conformers can trigger cascades of events ultimately resulting in cell dysfunction and death with devastating clinical consequences in many of the most precious aspects of human existence including personality, cognition, memory, and skilled movements.

This book, which is composed of a compilation of chapters authored by outstanding and well-published scientists in the respective fields currently performing active investigations at world renowned universities and research centers, focuses on the growing number of diseases associated with protein misfolding in the central nervous system. Individual chapters are dedicated to the most common neurodegenerative diseases associated with protein aggregation/fibrillization focusing on the nature of the pathogenic species and the cellular pathways involved in the molecular pathogenesis of Alzheimer's, Parkinson's, and Huntington's diseases as well as in Amyotrophic Lateral Sclerosis, and Prion disorders. A group of contributions is centered on the current knowledge of the intracellular pathways and subcellular organelles affected by the different disease conditions, while others are focused in the emerging pathogenic role of misfolded subunits assembled into neurotoxic soluble oligomers, and in the novel notion of the transmissibility of the protein misfolded species, an innovative concept until recently only accepted for Prion diseases. Lastly, a different set of chapters is dedicated to the evaluation of novel therapeutic strategies for these devastating diseases.

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SKU: 56693079521

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Sheila
Alexandria, US
★★★★★ 5
A soft, non clingy top that fits perfectly!
Color: Print 02, Size: X-Large
This is such a versatile top . The sleeves are a perfect length. The material is high quality and the colors are so pretty. It launders well with no wrinkles. I will definitely be ordering more tops from WIHOLL. Great top at a great price.
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Reviewed in the United States on May 14, 2026
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Sherry T.
Belleville, US
★★★★★ 5
Nice quality casual shirt
Color: Print 02, Size: Large
I love this shirt! It was true to size, color and fit! I washed it in cold water and dried on permanent press. Put on a hanger immediately out of the dryer - no wrinkles! No shrinkage and no fade. Materials is light but is not see thru.
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Reviewed in the United States on May 13, 2026
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Jean Lloyd
Lexington, US
★★★★★ 5
Very flattering
Color: Boho Print 03, Size: X-Large
Great shirts! I have a large bust, and they still look great! They're comfortable and don't cling, and they're machine wash and tumble dry low. This is my third one, and I may buy more.
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Reviewed in the United States on May 19, 2026
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Mary Williams
Port Orchard, US
★★★★★ 5
Great feel and color
Size: Medium, Color: Ocean Depths, Size: Medium, Color: Ocean Depths
Absolutely love this tank top! The color is gorgeous and exactly like the pictures — super vibrant and flattering. The ribbed material feels soft but still has enough stretch to hug in all the right places. I also really like the built-in padding and racerback style because it makes it easy to wear without needing extra layers. The only thing I would mention is that it runs a little small, especially if you want a more relaxed fit. I’d recommend sizing up if you’re between sizes. Other than that, it’s a great basic top that looks cute dressed up or casual!
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Reviewed in the United States on May 20, 2026
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Jane of all Trades
Birmingham, US
★★★★★ 5
Vibrant Racer Back Tank !!!
Size: X-Small, Color: Hot Pink, Size: X-Small, Color: Hot Pink
I purchased this Danysu V Neck Racer Back Tank Top for Women Padded Ribbed Long Tank Fitted Basic Cami Tops to wear under my off-shoulder top for an upcoming 80’s dance party, and it works perfectly for what I needed! The bright pink color really pops and adds the perfect retro accent to my outfit. I intentionally ordered the XS because I did not want it to fit loose under my top, and it definitely gives a snug, fitted look. The ribbed material is soft and stretchy, and the built-in padding is a nice bonus. I would recommend sizing up if you plan to wear it alone or if you are curvier, as the XS runs very tight. However, for layering under another top as I did, it worked out exactly the way I wanted. Super cute, flattering, and great for layering or workouts!
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Reviewed in the United States on May 24, 2026

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