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Description
human bsep vesicle kit hek293Das Human BSEP Vesicle Kit enthlt Inside out Membranvesikel aus HEK293 Zellen, die transient die Bile Salt Export Pump (BSEP ABCB11) berexprimieren. BSEP ist der primre hepatische Efflux Transporter fr Gallensalze und ein zentrales Zielprotein in der Risikoabschtzung fr medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017) und EMA (2013) Leitlinien fr DDI Studien. Hergestellt von Cell4Pharma. Exklusiv im DACH Raum erhltlich
Das Human BSEP Vesicle Kit enthält Inside-out Membranvesikel aus HEK293-Zellen, die transient die Bile Salt Export Pump (BSEP / ABCB11) überexprimieren. BSEP ist der primäre hepatische Efflux-Transporter für Gallensalze und ein zentrales Zielprotein in der Risikoabschätzung für medikamenteninduzierte Cholestase (DILI). Das Kit ist konform mit den FDA (2017)- und EMA (2013) Leitlinien für DDI Studien.
Hergestellt von Cell4Pharma. Exklusiv im DACH-Raum erhältlich über SeamlessBio.
Transporter-Profil
Name: BSEP, Bile Salt Export Pump, ABCB11, ATP-bindende Kassette Unterfamilie B Mitglied 11
Gen: ABCB11
ATP/AMP-Ratio: >10 (garantiert)
Gewebsexpression: Kanalikuläre Plasmamembran der Hepatozyten
Erkrankungen: Erbliche und medikamenteninduzierte Cholestase (DILI)
Bekannte Substrate: Taurocholat, Pravastatin, Taurolithocholyl-3-Sulfat, konjugierte monovalente Gallensalze
In stock: Human, Katze, Hund
Kit-Inhalt (100 Reaktionen)
- Vesikel-Vial (100 Reaktionen), BSEP überexprimierende HEK293-abgeleitete Vesikel
- AMP-ATP-Lösung (100 mM), Cell4Pharma
- Assay-Puffer, Cell4Pharma
Anwendungen
- allensalztransport-Inhibitionsstudien (Cholestase-Risikoabschätzung)
- Drug-Induced Liver Injury (DILI) Screening
- Drug-Drug-Interaction-(DDI)-Studien gemäß FDA/EMA-Leitlinien
- Substratidentifikation für hepatische Efflux-Transporter
- High-Throughput-Screening (Radiolabel-, Fluoreszenz-, LC-MS-Detektion)
Regulatorische Konformität
Die Hemmung von BSEP ist ein etablierter Mechanismus der medikamenteninduzierten cholestatischen Leberschädigung. Die Bewertung der BSEP-Hemmung wird in den FDA (2017)- und EMA (2013)-DDI-Leitlinien als Teil des Transporter-Charakterisierungspakets für neue Molekülentitäten (NMEs) in der klinischen Entwicklung empfohlen.
Technische Spezifikationen
Wirtszelle: HEK293 (humane embryonale Nierenzelle)
Vesikeltyp: Inside-out-Membranvesikel
Format: 100 Reaktionen pro Kit
Detektion: Radiolabel / Fluoreszenz / LC-MS kompatibel
Lagerung: –80 °C
Verwandte Produkte
- Human Control Vesicle Kit (C4PVK009) – empfohlen als Negativkontrolle in BCRP-Transportassays
- Human MRP2 Vesicle Kit (C4PVK002) – for parallel hepatic efflux assessment
- Human BCRP Vesicle Kit (C4PVK006) – for complete efflux transporter panel
- ciPTEC-OAT1 Assay-Ready Cells – für zellbasierte Nephrotoxizitäts- und Transporterstudien
- Human Serum AB Male OTC (SeamlessBio) – zur Supplementierung von ciPTEC-Kulturmedien
Alle Produkte auf Anfrage.
Kontakt: [email protected] | Telefon: +49 851 37932226
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4.7 ★★★★★
Based on 17 reviews
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Product Reviews
★★★★★ 5
Great message to send the kiddos
Format: Board book
Such a good message for the kiddos. Leave had this book since he was an infant and we still read it often 2.5 years later.
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Reviewed in the United States on April 7, 2025
★★★★★ 5
Great shower gift. Gave as card and it cost close to as much as a card.
Format: Board book
Sweet story.
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Reviewed in the United States on November 1, 2025
★★★★★ 5
Favorite book!
Format: Board book
I love reading this book to our baby! It’s sweet and fun to read. ☺️
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Reviewed in the United States on December 28, 2024
★★★★★ 5
The Best Fluoride-Free Toothpaste I've Tried
Flavor Name: 1. Sensitive Mint, Size: 5.25 Ounce (Pack of 1)
I've been using Davids Hydroxi Fluoride-Free Nano Hydroxyapatite Toothpaste for several weeks, and it has completely exceeded my expectations.
The first thing I noticed was how clean and smooth my teeth felt after brushing. Unlike many natural toothpastes, it leaves a genuinely fresh feeling without being overly harsh. The natural peppermint flavor is refreshing and pleasant without the intense burn that some mint toothpastes have.
What really impressed me is the nano-hydroxyapatite formula, which is designed to support enamel remineralization and reduce sensitivity. My teeth have become noticeably less sensitive to cold drinks, and they feel stronger overall. Nano-hydroxyapatite is gaining attention as a fluoride alternative because it can help replenish minerals in enamel and reduce sensitivity.
I also appreciate that it's:
Fluoride-free
SLS-free
Made in the USA
Vegan
Uses high-quality ingredients
Comes in a recyclable metal tube
The whitening is subtle but effective. My teeth look brighter without any increased sensitivity, and the toothpaste is gentle enough for daily use. The inclusion of xylitol and hydroxyapatite makes it feel like a premium oral care product rather than just another natural toothpaste.
While it's more expensive than conventional toothpaste, the quality and ingredients justify the price. Even dental professionals reviewing hydroxyapatite toothpastes have noted benefits for remineralization, sensitivity relief, and plaque reduction.
Overall: 5/5 stars. If you're looking for a fluoride-free toothpaste that supports enamel health, helps with sensitivity, and leaves your mouth feeling exceptionally clean, Davids Hydroxi is absolutely worth trying. Highly recommended!
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Reviewed in the United States on June 3, 2026
★★★★★ 5
Mild mint taste
Flavor Name: 1. Sensitive Mint, Size: 4 Ounce (Pack of 1)
I wanted to go fluoride free with my toothpaste so I decided to give this a try. I like that the flavor isn’t overly strong and it hasn’t caused any irritation at all. It doesn’t foam up as bad as my old toothpaste did. It is important to me that it’s all natural and fluoride free. My first check up at the dentist after using it went really well so it cleans your teeth really well. I would recommend it
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Reviewed in the United States on May 28, 2026